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Grant will support Olm’s research on how diet and lifestyle shape the infant gut microbiome and immune disease risk

Matthew Olm, a University of Colorado Boulder assistant professor of integrative physiology, has been named a member of the .

Olm is one of eight early-career biomedical researchers at four leading Colorado academic and research institutions who each will receive a $250,000 grant through the Boettcher Foundation’s Webb-Waring Biomedical Research Awards Program to fund up to three years of independent scientific research.

The Webb-Waring Biomedical Research Awards provide critical early-career support and position recipients to compete for additional private, state and federal research funding while helping Colorado retain top scientific talent, according to the Boettcher Foundation.

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Matthew Olm, a University of Colorado Boulder assistant professor of integrative physiology, has been named a member of the .

“The awards are critical to Colorado’s future because of the investment in researchers at one of the most important stages of their careers, when bold ideas have the potential to create lasting impact,” said Katie Kramer, president and CEO of the Boettcher Foundation, in an announcement of the awards. “Colorado’s leadership in bioscience depends on ensuring that emerging researchers have the resources to pursue innovative work.”

The Boettcher grant will support Olm’s research on how diet and lifestyle shape the infant gut microbiome and immune disease risk.

“Immune diseases like asthma, allergies and type 1 diabetes have exploded in industrialized countries over the past 100 years, but they are still rare in non-industrialized settings,” Olm says.��“The microbes that colonize infant guts in the first year of life appear to be critical for training the human immune system, and we hypothesize that something about modern life is disrupting this process. This funding gives us the ability to compare infant microbiomes across the globe using cutting-edge immunological and bioinformatics techniques. We hope this work will ultimately lead to the development of strategies to restore the infant microbiome to its historical state to prevent immune diseases before they start.”

Olm, who earned his bachelor’s degree at the University of Pittsburgh and his PhD at the University of California Berkeley, leads the Integrative Microbiome Research Laboratory, where he and his research colleagues study the human microbiome as “an entire ecosystem of microscopic organisms that live on our skin and inside our body. These microbes are integrated into our immune, digestive and nervous systems and are critical to our overall wellbeing.”

Olm and his colleagues aim to increase understanding of the human microbiome and its connections to physiology and to apply these findings to improve human health using cutting-edge, computer-based analysis and experimental techniques to study the microbiome.

The lab’s current research topics include:

• From where do we get our microbiome? How do our microbes spread from person to person?
• How does the infant gut microbiome influence the development of allergies and auto-immune disease?
• How does our intestinal immune system control our gut microbiome? How do failures in this control lead to disease?

������Ƶ the awards program

Since it began, the Webb-Waring Biomedical Research Awards Program has supported 121 Boettcher Investigators, including this year’s class, and awarded almost $29 million in grant funding. These researchers have gone on to secure more than $150 million in additional research funding from federal, state and private sources. The Boettcher Foundation’s Webb-Waring Biomedical Research Awards strengthen the state’s long-term competitiveness by helping emerging investigators accelerate breakthroughs for patients.

“Colorado’s future as a leading hub for health innovation depends on bold scientific thinking and sustained investment in emerging researchers,” said Elyse Blazevich, president and CEO of the Colorado BioScience Association, in an announcement of the awards. “The Boettcher Investigators are advancing high-impact discoveries across some of the most urgent challenges in human health while strengthening Colorado’s position as a center for biomedical research and innovation. These awards help accelerate breakthrough science, support exceptional talent, and reinforce the collaborative research environment that sets Colorado apart.”

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